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The two-state model of receptor activation has given way to multistate models with intermediate conformational states.
A soft omission threshold was used so that 20% of models with the lowest omission error were retained; those models with intermediate levels of commission were then chosen from this subset.
After checking the proportional odds assumption, we ran additional logistic models with intermediate (1 to 3 months) and long (>3 months) patient delay as two distinct binary outcomes.
The results confirm that the improved performance of the new model is due to a combination of (1) more flexible priors on divergence-time and demographic parameters that avoid placing high prior density in improbable regions of parameter space, and (2) a diffuse Dirichlet-process prior that does not strongly disfavor divergence models with intermediate numbers of divergence events.
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In contrast, detailed concentration histories need to be retained throughout analyses involving two-event models with intermediate-stage clonal growth advantage (clonal two-stage) and multistage models.
Finally, to determine if Beclin 1 would be rate limiting in a model with intermediate latency and penetrance, a tumor watch was performed on Lck-Bax1 mice that were either Beclin 1 wild type or heterozygous.
This study explored if combining treatment with an EGFR and an mTOR inhibitor in an SCC model with intermediate susceptibility to EGFR inhibition.
These variables were then included in a multivariable logistic regression model, with intermediate acting non-depolarizing neuromuscular blocking agents administered intraoperatively as the dependent variable.
Individuals S47, S35 and S37 are described by the model with intermediate dendrite lengths lasting longer than the one week simulation time, while S21, S19 and S26 exhibit longer dendrites over a shorter period of time.
For bacteriophage T7 RNAP, based on a kinetic model with intermediates suggested by single-molecule force and various structural studies, the transition from post to pre appears to have a small energetic cost consistent with movement of Tyr639 out of the NTP binding site.
To investigate the importance of GSK3β regulation during axonal regeneration in vivo, we used three genetic mouse models with high, intermediate or no GSK3β activity in neurons.
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