Sentence examples for models with inducible from inspiring English sources

In transgenic mouse models with inducible MYC, withdrawal of MYC expression induces breast tumour regression, indicating these tumours are addicted to MYC function for tumour maintenance [ 40- 42].

Because of the importance of HSP60 in many diseases, Tg mouse models with inducible and tissue-specific HSP60 expression can provide useful insights and expand the current understanding of these diseases.

Although constitutive overexpression of genes in transgenic rats has been successfully applied to generate relevant models for gene-related diseases [ 55- 57], only limited attempts have been made in the past to establish transgenic rat models with inducible and tissue-specific gene expression and no one has successfully addressed the brain [ 58].

In addition, SCNT using pools of stable transfected cell clones was an efficient way for the production of transgenic founder pigs with appropriate expression patterns (reviewed in [ 1, 9]) and facilitated the generation of the first pig models with inducible transgene expression [ 10].

Cell line and mouse models with inducible expression of ATZ have been particularly valuable for identification of these pathways because these types of systems are less prone to cellular adaptations that potentially occur in systems with constitutive expression of the mutant protein.

To examine the autonomy and mechanism of p16INK4a-induced senescence, we utilized a melanoma cell model with inducible, physiological levels of p16INK4a expression and compared the impact of wild-type p16INK4a expression to that of two functionally distinct p16INK4a melanoma-associated mutants.

OVX-immunocompromised mouse is an established model with inducible osteoporosis phenotype that allows testing whether CD4+CD25−CD45RB+hi T cell can induce osteoporosis like bone density alteration in vivo.

The TMA observed in Ehd3 /–; Ehd4–/– glomeruli bear a striking resemblance to that seen in mouse models with reduced podocyte VEGF expression and a recent mouse model with inducible whole-body deletion of VEGFR2 [40].

Specifically, a mouse model with inducible podocyte-specific Ang-2 expression resulted in albuminuria and glomerular endothelial apoptosis (36).

Employing a mouse model with inducible, acute β-cell ablation, we uncovered an essential role of adiponectin under insulinopenic conditions to maintain minimal lipid homeostasis.

Using a conditional knock-out model with inducible deletion of BDNF, we here show that clinical symptoms and structural damage are increased when BDNF is absent during the initiation phase of clinical EAE.