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In addition, a special feature from case 3 and 4 is analyzed, which is useful in order to achieve a lower TAC by using modified Stage-Wise Superstructure (SWS) models with flexible utility placement.
Handling molecular docking experiments on FFR models with flexible ligands still constitutes a big challenge, since it may take hours, days, or even months to be completely executed for a single ligand.
The assumption of linear exposure-response was assessed graphically and by fitting alternative models with flexible spline functions and was found to be adequate.
We achieved this by incorporating a specific parameter for the change in official cause of death coding policy in Poisson regression models with flexible restricted cubic splines to model time trends [ 20, 21].
During the local refinement procedure, a small initial perturbation was added to the subunits in low-resolution models first, then side chains were added, by a Monte Carlo Minimization which optimized both the backbones and side chains, and finally, a fast simulated annealing step was employed to relax the full atomic models with flexible backbones.
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LADM is a simple model with flexible and extensible elements based on the pattern "people – land" relationships (Fig. 1).
A planar rod model with flexible cross-section has been recently proposed in literature (Guinot et al., 2012).
The propagation along the cables is analytically modelled with flexible multi section cascading features utilizing frequency dependent scattering parameters.
A flexible sidechain model with flexible dihedral angles for up to 12 aminoacids increased both binding propensity and enrichment rates: EF_1 values increased by 35% on average with respect to rigid-docking (3-8 flexible sidechains).
A planar rod model with flexible cross-section has been proposed and discussed recently in literature (Guinot et al., 2012; Picault et al., 2014).
Zerafat Angiz et al. (2009) proposed a multi-objective linear programming DEA based model to select the best alternative in a group decision-making environment Contreras (2010) presented a distance-based consensus model with flexible choice of rank-position weights in which preference aggregation is obtained by a ranking of alternatives.
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Justyna Jupowicz-Kozak
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