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Animal models with expression deficits of KCC2 orthologues have been described.
Next, Marty and co-workers and Mullally and colleagues independently reported mouse JAK2V617F knock-in models with expression of mouse JAK2V617F under the control of the endogenous promoter.
To search for a potential causal role of MeCP2 in the development of cardiac hypertrophy and failure, 3 mouse models with expression or ablation of MeCP2 in cardiomyocytes were generated (Online Figures IV and V).
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Further, the article presents how performance values can be specified on UML models with expressions using MARTE Value Specification Language (VSL).
This conclusion is consistent with the observation that JNK2-deficiency increases breast cancer in a transgenic mouse model with expression of polyoma virus T antigen [24].
The Cis-correlation between CSPP1 expression and DNA copy number variation was quantified by Pearson correlation and was also explored by a univariate linear regression model with expression values as variable and copy number variation as response.
As further validation, we constructed a linear model with expression divergence as the dependent variable, and the 11 tested factors and d N as explanatory variables; d N remained highly significant in this analysis (P < 10−).
In an attempt to clarify the origin of this phenomenon, we have developed an inducible transgenic mouse model with expression of the most common HGPS mutation in brain, skin, bone and heart to investigate how the mutation affects these organs.
We foresee two main future directions of this study: first, the expansion of the TRN model with expression data from other phenotypic transitions, e.g., starvation on other nutrients, different growing conditions (light, trophic conditions, CO2 levels, etc)., and different mutant strains.
To predict gene expression in lung, we built gene-specific linear regression models with gene expression in lung as outcome and the gene expression in blood, age, and gender as predictors.
In this study, we compared the efficacy of 213Bi-DOTATATE TAT in tumours of different sizes in two different tumour models, both with expression of SSTR2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com