Sentence examples for models with deficiencies from inspiring English sources
Studies in mouse models with deficiencies in some AMP genes underline the importance of these molecules in protecting the host epithelia against bacterial infections [4] [6].
The role of PtdIns3 P in stimulated platelets is still unknown and the development of mouse models with deficiencies in enzymes involved in its metabolism might bring new light on the functions of this lipid in the near future.
Several mouse models with deficiency in the ING1 locus have been described [ 19, 22].
Multiple mouse models with deficiency of Cdkn1c recapitulate some aspects of BWS but do not exhibit overgrowth of the newborn, a cardinal feature of patients with BWS.
Two zebrafish (Danio rerio) models with deficiency in nipbl 47 and esco2 48 have been generated to explore the molecular mechanisms causing the phenotypes observed in CdLS and Roberts syndrome.
Until recently, our laboratories and others have developed mouse models with genetic deficiencies in glutamate-cysteine ligase (GCL), the rate-limiting enzyme in the GSH biosynthetic pathway.
Animal models with engineered deficiencies in certain complement proteins have demonstrated that widespread complement activation after severe injury culminates in complement dysregulation and excessive generation of complement activation fragments.
To further understand the role of BMP and TGFβ signaling in the postnatal growth plate and to elucidate potential crosstalk between both signaling pathways we generated and compared two mouse models with partial deficiency of either BMP or TGFβ signaling in the growth plate.
Animal models with genetic deficiency may provide probabilities to reveal the pathogenesis and treatment of AS [ 26].
From animal data, benefits are not limited to GLP-1R agonists, which are given at pharmacologic doses, but also in models with DPP4 deficiency or inhibition.
Animal models with rps19 deficiency have to be created (Matsson et al, 2004) to test therapeutic efficacy of the viral vectors.
