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In a second part, βhigh and βlow-cell distribution and functionality were investigated in animal models with decreased or increased β-cell function: the Zucker Diabetic Fatty rat and the 48 h glucose-infused rat.
To determine the role of mTORC2 signaling in mammalian lifespan, we first examined two different mouse models with decreased expression of RICTOR, an essential protein component of mTORC2.
Recently, several mouse models with decreased numbers of recombination sites per chromosome have been reported (e.g. the Tex15 and Ews knockout lines) (Li et al., 2007; Yang et al., 2008).
These genetic models with decreased CREB activity show enhanced CPP and sensitization to cocaine compared with wild-type controls [ 25, 26], further supporting CREB mediation of the negative aspects of cocaine.
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To disprove the converse of the Barcan formula we need models with decreasing domains.
However, scenarios assuming increasing levels of non-AIDS mortality resulted in implausibly low estimates of peak prevalence (11%), whereas models with decreasing underlying crude mortality could be consistent with the prevalence and mortality data.
We used the inner training set to train reduced nested Cox models with decreasing numbers of variables from n-1 variables to one variable.
Although models with decreasing number of freely estimated parameters did not markedly differ in their RMSEA, their CFI and SB χ2 differed significantly from the less restrictive model and, obviously, also from the baseline model.
We report that rapamycin, an mTOR inhibitor, restored cardiac function in a passively β1-AAB-immunized rat model with decreased cardiac function and myocardial autophagic flux.
In support of this notion, the lung structure was preserved in a transgenic mouse model with decreased chymotrypsin-like proteasome activity while these mice developed age-related phenotypes such as kyphosis, loss of skeletal muscle mass and adipose tissue and died prematurely [ 18, 46].
The results are consistent with the spherical particle model with decreasing core and chemical control.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com