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On the other hand, genetic models with chronic liver inflammation develop HCC at a high rate [11] [13].

CD73 levels are up-regulated in the lungs of mouse models with chronic lung disease including ADA-deficient mice and mice exposed to bleomycin [25], [27].

Second, the expression of PPL was examined in models with chronic damages from hepatic fibrosis or steatosis.

Moreover, as with PAH, TWEAK blood plasma levels are decreased in patients and animal models with chronic kidney disease (CKD).

Acute ischemic injury causes rapid neuronal damage, whereas in models with chronic stress, such as models of chronic neurodegeneration disorders, the effects of RTDL deletion could be different.

Both MMP-2 and MMP-9 are highly expressed in the tubular compartment in animal models with chronic kidney disease, and they were also found in the serum of patients with chronic kidney disease [ 28, 46, 47, 119].

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Here we used a mouse model with chronic GSH deficit induced by knockout (KO) of the key GSH-synthesizing enzyme, glutamate-cysteine ligase modulatory subunit (GCLM).

Three approaches or a combination of approaches can be used to determine the myocardial substrate underlying the chronic dysfunction Open image in new window Fig. 12 Relation between myocardial substrate and functional response during low-dose and high-dose dobutamine stress in an animal model with chronic myocardial ischaemia.

A rat model with chronic rotenone exposure seems to reproduce pathophysiological conditions of PD more closely than acute mouse models as manifested by neuronal cell death in the substantia nigra and Lewy body-like cytosolic aggregations.

Patients entered the model with chronic HCV and immediately began AV drug therapy.

In addition, to explore the effects of dyclonine in an additional model with chronic dosing, we treated FA-PandKIKO mice [ mFxn+/− with FXN (GAA)230 expansion; m Fxn−/−] with 25 mg/kg dyclonine for 4 weeks p.o.

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