Sentence examples for models with alterations from inspiring English sources

Similar results were previously shown using mouse models with alterations in other components of TGF-β signaling, including Smad3, LTBP3 and Smurf2 [ 7- 9].

Studies on in vivo breast cancer models with alterations in the PI3K pathway should increase our understanding of this complex but fascinating signaling network, test the validity of this speculation and optimize combination therapies.

Together with mouse studies of neuroligin-3 (Baudouin et al., 2012) and Fragile X mental retardation 1 (Koekkoek et al., 2005) and a valproate rat model of autism (Stanton et al., 2007; Murawski et al., 2009), our work brings to eight the number of autism rodent models with alterations in cerebellum-dependent function.

Several animal models with alterations in Wnt-related gene expression show partially overlapping phenotype: the well-known masterblind (mbl) mutant, which develops reduction of the telencephalon, optic vesicles,and an abnormal AP patterning, was found to be a spontaneous axin1 mutant.

Septic shock is a complex physiopathologic model with alterations in the microcirculation, occurring together with changes in biochemical and physiologic characteristics of the blood.

After systemic delivery into the areas of muscle injury and inflammation, they have been shown to migrate outside the vessel and to restore the structure and function in a mouse model of muscular dystrophy [ 47] and in a dog model with alterations of dystrophin gene that develops the full range of human pathology [ 48].

For example, in the models with genetic alterations, although the proteins encoded by the genes of human and rodents are highly homologous, the regulation of gene transcription by transcription factors or epigenetics, or the regulation of gene translation by microRNAs, can vary extensively between humans and rodents.

Other proteins may be part of the TGFβ Smad2/3 IKKα signalling pathway, as revealed by two mouse models with functional alterations of 14-3-3σ 14-3-3σ 14-3-3σtion mutant mice) and Irepeated disruption of which faithfully mimics thepilationpe of Ikkα–/– mutantHerron et al, 2005; Li et al, 2005b; Ingrahamice and 2006; RIRF6rdson ethel, 2006).

To model SD site-dependent extension of footprint lengths, footprints were generated under a similar model with two alterations.

However, as other GLP-1 receptor agonists have similar modes of action as liraglutide, it is believed that the model with minor alterations can also be used to describe glucose homeostasis in T2DM patients treated with other GLP-1 receptor agonists.

The results of the proposed in vivo lung injury model are consistent with alterations known to occur in VILI.