Sentence examples for models with acute from inspiring English sources

Recently, more viable GCase mouse models with acute neuronopathic Gaucher disease have been generated (19, 20).

The fact that protein expression of the collagenases MMP-1 and MMP-13 was accompanied by elevated TIMP-1 levels is compatible with results in chronic pressure- overload induced hypertrophy but contrasts to models with acute pressure-overload showing an increase in MMP activity [ 22]. β1TG mice developed dilatation and heart failure at the age of 12 months [ 11].

This study is designed to investigate the effect of 1,25(on)2D3 on ethanol-induced intestinal barrier dysfunction and the underlying mechanisms utilizing Caco-2 cell monolayers and a mouse model with acute ethanol injury.

In brief, modeling with acute traumatic brain injury models in the midbrain or sensory-motor cortex, RADA16-I SAPs nanofiber scaffold was found to bridge the injury gap, to reconstruct the lesion cavity, and/or to promote knitting of the wounded tissues.

To evaluate this hypothesis, a rat model with acute myocardial infarction was used, and the therapeutic hydrogels were injected intramyocardially in the peri-infarct regions.

We have demonstrated for the first time in the literature that acute hyperglycemia with no preceding diabetes mellitus abolished the infarct size limiting effect of RIPerC in an in vivo rat model with acute coronary occlusion and reperfusion.

The ultrastructural changes in AECIIs after high-frequency oscillatory ventilation (HFOV) with a high lung volume strategy or conventional ventilation were evaluated in a newborn piglet model with acute lung injury (ALI).

In addition, Wnt4 mRNA and protein expression significantly increased in the proximal tubules of an animal model with acute kidney injury and activation of Wnt/ β-catenin was involved in the cyst formation of polycystic kidney disease [ 49].

The goodness of fit of the multivariable regression model was tested by the Hosmer-Lemeshow statistic: P = 0.080 for the model with acute kidney injury as the endpoint, and P = 0.019 for the model with maximum Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) class failure as the endpoint.

See related research by Engström et al., http://ccforum.com/content/14/3/R93 The prospective investigation by Engström and colleagues in a previous issue of Critical Care sets out to determine if apneic oxygenation via a pharyngeal catheter during endotracheal intubation would prevent or increase the time to life-threatening hypoxemia in an animal model with acute lung injury [ 1].

We then investigated whether the deregulation of Notch signalling occurred early in β-catenin-induced intestinal tumorigenesis, by analysing Hes1 expression in a conditional mouse model with acute APC loss in the adult intestinal epithelium (Apclox/loxVil-CreERT2). 3 In this system, Apc was deleted in response to tamoxifen injection (Apc-null mice, Apc−/−).