The α-CaMKII hKO mice are the best characterized iDG mouse model with behavioral abnormalities such as hyperactivity, working memory deficits and social withdrawal, which are analogous to those in patients with bipolar disorder/schizophrenia 15, 19.
Advanced GEM models with multiple genetic abnormalities, able to generate both hormone sensitive and insensitive tumours and in which metastasis occurs at clinically relevant sites will also be a desirable refinement [ 376, 377].
Notably, increased production of citrullinated peptide autoantibodies has been demonstrated in two murine model systems of autoimmunity with abnormalities in B cell apoptosis, whereas anti-CCP responses were not associated with other autoimmune models that included the classical collagen-induced arthritis system [ 40].
Furthermore, Li has demonstrated to improve diurnal activity rhythm and periodic activity alterations in transgenic mice with neuron-specific expression of mutant Polg (D181A) - an animal model with generated chronobiological abnormalities (Kato et al. 2007).
Therefore potential causal relationships between altered systemic lipoprotein levels and skin abnormalities in mouse models with Tg overexpression of particular forms of sPLA2 should be taken into account.
The only official campaign finance report Americans Socially United filed last year was riddled with abnormalities.
According to previous studies, several human patients and genetically-modified mouse models with body wall phenotypes often have accompanying digit abnormalities [3], [20], [26], [28], [47], [51], [53].
Assessment of lung function parameters in the single-dose elastase model showed abnormalities consistent with human COPD including increased FRC, TLC and increased dynamic lung compliance associated with elastase administration (elastase + UV compared with PBS + UV-treated mice; Figures 6a– 6a).
Those variables were then included in a multivariable model with each cytogenetic abnormality entered as a separate term.
Individuals with DS have several neuroanatomical abnormalities, including a smaller cerebellar volume (17– 20), that correlates, in DS mice models, with a reduced granule cell density (21– 21).
