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These analyses were tackled by applying random intercept repeated-measures mixed models where individual was entered as a random effect and the linear and second order polynomial terms of age as predictors together with sex.
We begin by fitting joint models where individual growth trajectories are linear.
Several animal models, where individual NER genes were disrupted, had showed the importance of the integrity of NER pathway in preventing lung cancer [ 24, 25].
We therefore restricted our modelling to linear growth models where individual trajectories were summarised by an intercept, reflecting initial performance level, and a single slope, reflecting linear rate of change over time in each dependent variable.
Moreover, as QSSPN allows incorporation of quantitative rates, it offers the exciting prospect of building semi-quantitative models where individual trajectories are interpreted as different cellular behaviours occurring in a population of genetically identical cells because of stochastic phenotypic switching (Balaban et al., 2004).
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The most important conclusion of the paper, i.e. that dynamic models predict much more variability than models where individuals are independent and hence are sufficient to explain highly variable prevalence data, would remain true for more complex model.
The models we refer to as SIS (see Figure 1) are not classical SIS models where individuals become fully susceptible to reinfection following clearance.
Thus, in our model dynamics emerge that are similar to those that have been observed in spatial models where individuals are embedded in static spatial structures in which each individual has a fixed position and thus a fixed number of interaction partners [ 15- 18].
This phrase refers to the increasingly popular cloud-computing model, where individual users tap into online services delivered via a data center rather than running software directly on their PCs.
Liter of Light provides a model where individual entrepreneurs can learn to make and install the devices and sell them on to their communities at a small profit, thus kick-starting grassroots green economies such as the one in San Pedro Laguna in the Philippines, where a single local entrepreneur has installed 11,000 solar bottles.
At the time, around 70% of its bookings were via the so-called "collaborative consumption" model where individual space owners would rent out their spaces to other drivers.
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