Since each AKAP150-anchored enzyme influences distinct metabolic events, we investigated glucose homeostasis in mouse models where discrete elements of the AKAP150 signalling complex were disrupted.
Instead of constructing and evaluating a single prediction model which includes all covariates of interest, we construct and evaluate a set of prediction models, where each model contains a distinct set of covariates for each subset of observed covariates.
We use a combination of simulation results and simple theoretical models to define critical fibril lengths where distinct failure mechanisms dominate.
For instance, the two-step floating catchment method (a modified gravity model) has been employed in instances where distinct differences or thresholds exist between what is considered accessible and what is deemed inaccessible [ 49].
The ecotype model explains well the patterns of divergence observed in Bacillus spp. from Evolution Canyon, Israel, where distinct genetic clusters occur in ecologically distinct locations within the canyon (Cohan and Perry 2007).
Two distinct models which differ in the definition of time t in the transition functions have been studied: semi-Markov models where the transitions depend on the waiting times and nonhomogenous Markov models where the transitions depend on the time since inclusion in the study.
These findings contrast sharply with our results for the null model, where no evolution of distinct phenotypic clusters occurs.
The occurrences of genomic intervals are described by a simple finite mixture model, where each component represents a distinct cooccurrence pattern.
We estimated, using AICc, if a model where clownfishes and damselfishes have distinct rates explains the observed data better than did a model of common rate between the two groups.
For example, in the case of a population genetic model, where the components correspond to distinct panmictic populations, we might want to compute the marginal posterior distribution of the frequency of a particular allele type in each population.
