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The tax-benefit systems included in the model have been validated against aggregated administrative statistics in order to make sure they reflect the initial baseline conditions in each country as well as national tax-benefit models (where available), and the robustness checked through numerous applications (see e.g. Bargain (2006)).
In our models, where available, we have relied on in vivo and in vitro biochemical experiments for parameter values [ 26, 44- 49].
Again, only when 200 models where available for the estimation of the entropy criterion the performance of the method was comparable with that of the maximum difference approach.
Evidence from reported statistical models, where available, was considered in the evaluation of vision in the better-seeing eye and the worse-seeing eye.
Third, more translational research using human analogous animal models, where available, would make a significant contribution to the understanding of the disease and treatment by providing histological and molecular validation for both mechanistic and therapeutic drug studies.
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For five LQTS genes, the burden in cases is estimated both from literature reports and from a prospective case series; the latter are used in our model where available.
In addition to this basic information, the database also aims to record modelling information where available, as well as sample images and appropriate references.
For the purposes of model fitting, where available we used estimates of key biochemical parameters as reported in [ 42].
The use of technology has been speculated to lead to new evolving patient-driven healthcare models, where the information available will not only empower the patients in being more engaged on their conditions, as our participants also revealed, but will also influence how clinicians deliver treatment and use the information collected to make new recommendations.
Figure 5 Drug time-to-peak values for the present model and literature models (data are represented where available and upon conversion of units of measure).
Figure 4 Drug peak concentration values for the present model and literature models (data represented are where available and upon conversion of units of measure).
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Justyna Jupowicz-Kozak
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