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In animal models, when given at the early stage, vasopressors were shown to be capable of restoring a quasi-normal hemodynamic status by mobilizing nonconstraint venous blood volume and thus normalizing arterial blood pressure, cardiac output, and preload parameters, such as pulse pressure variations [18].
TFV effectively blocked transmission of SIV or SHIV in non-human primate models when given as pre- or post-exposure prophylaxis systemically or when applied as an intravaginal gel [6], [7].
Biological based therapies that work well in rodent models when given before challenge have typically not worked in human sepsis patients.
CGRP receptor antagonists did not have activity in preclinical models when given into the trigeminal ganglia or onto the dura, but can inhibit activity of second-order neurons when given into central sites in the nucleus caudalis.
Anticoagulants are highly effective in attenuating fibrosis in experimental animal models when given either prophylactically (Howell et al., 2001; Scotton et al., 2009) or therapeutically (Gunther et al., 2003).
Animal studies with SBECD have not shown discrete changes in renal morphology at doses used clinically [ 11]; moreover, SBECD is not nephrotoxic in these models when given at dose equivalents of naturally occurring cyclodextrins that are associated with nephrotoxicity and/or hepatotoxicity.
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In almost every test case, both MEDELLER and Modeller could create a better core model when given only a single template structure (e.g. the one with the highest sequence identity to the target).
All methods were capable of calibrating the model when given enough computation time.
The methoxy prodrug of CPD0802 also cleared the GVR35 mouse model when given orally.
It is not known whether aspirin retains its efficacy in this model when given only during embryogenesis and weaning, without being present in the diet thereafter.
Importantly, we demonstrate that VX-166 improves survival in a caecal ligation and puncture (CLP) model when given several hours post insult.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com