Sentence examples for models when administered from inspiring English sources

Other antibodies, Fab, peptides and growth factors have been shown to exert beneficial effects on animal models when administered within the therapeutic and safe window.

1,3-Dicyclohexylurea, a potent and selective inhibitor of soluble epoxide hydrolase (sEH), reduces blood pressure in hypertensive preclinical animal models when administered intraperitoneally using DMSO/corn oil as a delivery vehicle.

However, recent results demonstrated its in vivo activity in Ph-ALL xenograft models, when administered in combination with the mammalian target of rapamycin (mTOR) inhibitor rapamycin [25].

In addition, curcumin crossed the BBB and inhibited tumor growth in orthotopic glioblastoma models when administered through the tail vein [ 11] or injected i.p. [ 10].

One possibility is that folate might be protective only in neurotoxin-induced PD models, when administered at high doses, often prior to the neurotoxic insult.

The preclinical findings described offer evidence that the combination of CTLA-4 blockade with various chemotherapeutic agents that exhibit different mechanisms of action, including ixabepilone, paclitaxel, etoposide, and gemcitabine, elicited synergistic antitumor activity in murine tumor models when administered concurrently.

Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate.

The present study evaluates the ability of a novel chimeric peptide, AA501, to bind to opioid and substance P receptors and to produce antinociception in tail-flick and formalin tests, and in a neuropathic pain model when administered intrathecally to rats.

Our previous study [6] indicates that DFMO is effective in vivo in a mouse model when administered continuously after inoculation with H. pylori.

Indeed, the preclinical evaluation of a monoclonal antibody against CD40 has shown beneficial activities in an MS model when administered early in the disease development, as well as after the onset of brain inflammation [27].

Dexmedetomidine could decrease intraparenchymal pressure in the transient global cerebral ischemia model when administered at low doses [ 1, 2].