Sentence examples for models were mediated from inspiring English sources

We thus speculated that the in vivo effects of thiacremonone on arthritic models were mediated by its combined inhibitory actions on multiple responses of synovial cells and inflammatory cells through the inactivation of NF-κB.

We may therefore conclude that modifications to neural excitability in previous immobilization models are mediated by long-term nervous system plasticity rather than acute mechanisms, and there appear to be no robust changes in corticomotor or spinal excitability acutely posed by ambulation with immobilization devices.

These two models are mediated by different mechanisms.

It is unlikely that the cross-protection against HSV-1 in the intravaginal and skin scarification models is mediated by antibodies to gD-1 as the immunoblots indicate only low levels of anti-gD antibodies.

Several lines of evidence have suggested that arthritis in mouse models is mediated through production of IL-17 by Th17 cells and is negatively regulated by the presence of IFNγ [ 6, 8, 9, 30].

The second incongruity - the divergence of anti-arthritic efficacy between AIA and CIA - reflects the twin facts that CIA is a milder disease than AIA and that progression of the two models is mediated by distinct immunopathogenic mechanisms [ 41].

LeCouter et al. 5 reported that the major effects of VEGF-A in protecting the liver from chemical injury in a murine model were mediated by way of VEGFR-1; in contrast, our studies demonstrate a role for endothelial VEGFR-2-mediated p38 MAPK activation in regulating BMP4 expression.

The present study demonstrates testosterone administration improves hypertrophy in myoblasts that basally display impaired differentiation and hypertrophic capacity vs. their parental controls, the action of testosterone in this model was mediated by PI3K/Akt pathway.

In summary, we find that the pelvic pain in an IC model is mediated by mast cell histamine acting on H1R and H2R.

The interactions between Im7 and Spy in the model are mediated by a combination of electrostatic and hydrophobic interactions.

The downstream feedback regulation in the model is mediated by phosphoprotein phosphatase 1 (PP1), which is known as a major regulator of ATF4 [ 23].