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By combining statistical modeling of genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation of >20 in vitro and in vivo resistance models, we discovered that major pathways of resistance converge to activate the transcription factor, c-MYC (MYC).
Of special note, nine of the unannotated mouse models we discovered (discussed earlier) encode predicted proteins with fingerprint patterns that match annotated genes in human and other species extremely well.
Using both stable and inducible T47D models, we discovered that MLL2 is significantly recruited to the MSX2 enhancer in progestin treated cells expressing SUMO-deficient KR PR, but not WT PR.
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Upon examining the parameters of these models, we discover that they have all negative coefficients and a negligibly small intercept, while having positive profits and good hit ratio.
Along with the improved gene models we discover new, more accurate means of identifying signal peptides in proteomics data.
"Using our computer model we discovered that the habitable zone for an Earth-like planet orbiting a sun-like star is about three times bigger if we include the top five kilometres below the planet surface.
By combining experiments with mathematical modeling, we discovered a reciprocal dose and duration response relying on the orchestrated action of three kinases (AtWNK1, AtWNK8, and AtWNK10) acting on distinct timescales and activation thresholds.
Using this zebrafish screening model, we discovered two independent suppressors (sunshine and eos) [ 2].
In agreement with the model, we discovered a positive correlation between LC3 level and AV size across single cells.
In cell model, we discovered the association between chaperonin-containing t-complex polypeptide 1 subunit β (TCP-1 β) and early diabetic nephropathy (DN).
By using the Rasch model, we discovered that specific items should be discarded and other items should be reformulated to make the questionnaire more "on target".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com