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Using PDX models, we confirmed the effectiveness and selectivity of the identified treatment responses.
Using both in vitro and in vivo injury models, we confirmed that HP-treated adipose tissue-derived mesenchymal stem cells (HP-AT-MSCs) increased cell survival and enhanced the expression of marker genes in DsRed-engineered neural stem cells (NSCs-DsRed).
Based on forward modeling with the anisotropic subsurface models, we confirmed that the characteristics of the observed receiver functions can be explained roughly by considering a localized anomaly in the upper and middle crust.
In these models, we confirmed in vivo the importance of caspase-8 in regulating the proinflammatory response of activated microglia.
Testing two mTOR inhibitors in our TNBC xenograft models, we confirmed in vivo growth inhibition in all.
In ex vivo models, we confirmed act-MMP-3 can be expressed by synovial membrane and oncostatin M and TNF-α stimulated human cartilage.
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Secondly, by comparing different immune deficient mouse models, we confirm that Rag2−/− γc−/− mice, which lack NK cells, are an ideal recipient animal model for MTLn3 and 4T1 cells to study the metastasis process.
Using this IAE model, we confirmed that the expression of histone methyltransferase Setdb2 was relatively higher in the brains of IAE model mice.
By culturing patient-derived tumor cells in the model, we confirmed the effects of mechanical signals on cancer cell survival and drug sensitivity.
By using pcD-alpha-globin cDNA as a model, we confirmed that the alpha-globin transcript produced in transfected cells is initiated correctly, spliced at either of the two introns, and polyadenylated either at the site coded in the cDNA segment or at the distal SV40 polyadenylation signal.
In the docking model, we confirmed that 4-chlorobenzene of 12 plays the parallel π π stacking against the indole ring of Trp84 in the bottom gorge of AChE.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com