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For both the participation and performance models, we built each model in several steps by adding variables.
First, although we used cross-validated training and in some cases additional activity data for model selection, due to the large number of models we built, it is possible that some models perfectly predict all training data, albeit by chance.
To rationalize their mechanism of action, we performed computational analysis utilizing molecular docking and dynamics simulations on the C. albicans and C. glabrata CYP51 (CandP51 and CGCYP51) homology models we built.
The regression models we built showed that, in many cases, there is a continuum of effects influencing the molecular state of a target pathway and that, in specific pathways, (i.e. Gap junction and ErbB signalling pathways) toxicity is observed either above or below a given threshold of pathway activity (Figure 5).
To efficiently manage and utilize information from the reconstructed models, we built the HMA website as an online resource to provide comprehensive information of human metabolism for further specific analysis as well as to provide a user-friendly interface for the research community.
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Monotheism is therefore not only a powerful constraint on the models we build, it is also a first step toward opening the quest for truth to outsiders and amateurs, who may see things differently than the establishment.
"The model we built [relying on foreign funding] was unsustainable," says Gasser Abdel Razek, executive director of EIPR.
In order to test phoneme recognition with a language model, we built unigram, bigram and trigram language models.
To show the effectiveness of the NWLBP model, we built our own discrete-event simulation model using C++ Builder 6 [21] 21].
We remind that the analytic model we built adopts the assumptions that no collision occurs and CW of each device keeps the minimum value.
The funding allows us to go out, take the economic model we built and as we scale we make more money.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com