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Following Lesnick et al. [ 2007], the best (minimum) P value over these five association models was retained and SNPs were ranked by this P value.
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Variables with a p-value <0.05 in multivariable models were retained in the final model.
Piecewise linear elastic laws usually used in cohesive zone models are retained in this work.
Only approved models are retained for the next step, otherwise the entire process is revisited to identify which alternative actions could be taken to improve the results (e.g., adjusting the problem definition or getting different data).
Once the exploration in each population was completed, then the MDs included in the built 9-variable models were retained with the purpose of creating new populations until 100 MDs.
It should be noted that higher fractions of models are retained in each successive step.
However, many models were retained for each of the two flux distributions with greater than a 60∶40 split ratio.
The variables that were found to be significantly associated with retention in the univariate models were retained in the multivariate models.
In screening for the overexpression of Tkt leading to an increase in the DAHP production rate, 122, 90, 575 and 534 models were retained for the 25∶75, 50∶50, 75∶25 and 95∶5 split ratios, respectively.
For autoshaping, four models were retained in the candidate set (Appendix Table A1).
For reversal learning speed, two candidate models were retained (Appendix Table A3).
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