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The systematic method with multiple statistical models was coded for numerical solutions, and demonstrated for eight HMA IC projects.
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The models are coded as part of the agent software.
The models were coded in the GAMS 24.1 software and executed by CPLEX solver.
Piloting the framework for two medicines, eight trials, 43 clinical endpoints and seven economic models were coded 155 times.
Various subsystem components in the models were coded as 'C' language S-functions and implemented in Matlab/Simulink.
Plant construction simulation was conducted by the Homer software, and all three modes of the mathematical models were coded in MATLAB.
All the models are coded in Lingo 14 and subsequently are exported to the interactive optimizer environment of CPLEX commercial software via the mps format.
Detailed descriptions of how the models were coded are presented in Table S1.
Mathematical expressions included in SBML models are coded following MathML specifications.
All 3D models were coded, and two observers (one maxillofacial radiologist and one maxillofacial surgeon) assessed the quality of all the models independently.
All models were coded in R (R Development Core Team 2007) using only the standard libraries and packages and are available from the lead author upon request.
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