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However, model integration is a complex task as different mathematical models usually do not adhere to a common modeling standard.
Such models usually do not yield closed formulas for maximum likelihood estimates, hence numerical methods such as the well-known Fisher scoring or Expectation Maximization (EM) algorithms are used in practice.
In addition, multiscale models usually do not require all the internal details of intracellular scales to have predictive value.
These models usually do not take into account variations in rates of transcription, translation, or cell growth among isogenic cells.
General prognostic models usually do not perform well in specific subgroups of patients because they may be under-represented in the developed cohort [ 6].
Prevalence-based and incidence-based models are often developed independently from the cost-effectiveness model, because those models usually do not require the complexity of a cost-effectiveness model.
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We conclude that the model usually does not converge to a fixed point, but instead it is bounded by a time-dependent finite region.
The ODE model usually does not differentiate regulatory action of sox17a and sox17b: both are regulators of hnf1β, foxa1, foxa2, gata4, gata5, gata6 and bix1.
For the dorsal endoderm circuitry, the ODE model usually does not differentiate regulatory action of sox17a and sox17b, while the Markov model sometimes splits their regulatory action and places more connections for sox17b.
This aspect allows us to define model-to-model transformations that not only provide a software artifact of lower abstraction (as model-to-model transformations usually do) but also to provide feedback about how they are applied.
Conventional PTA is based on analytical models which usually do not work for geothermal datasets, therefore PTA is under-utilised by the geothermal industry.
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