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We generated type 1 diabetic mouse models using streptozotocin injections.
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Two different mouse strains were fed with high-or low-fat diets, and compared with control mice and models in which diabetes was induced using streptozotocin (STZ).
To test this hypothesis, we investigated the effects of maternal diabetes on mitochondrial status in cumulus cells using streptozotocin (STZ -induced diabetic and Akita (inSTZ -induced mutant) mouse modiabetic
In the model of atherosclerosis-prone mice due to homozygous deletion of apolipoprotein E (apoE) gene, the induction of diabetes using streptozotocin resulted in atherosclerosis of increased severity compared to euglycemic apoE controls.
In a recent study, we compared the diabetic myopathy in the Ins2Akita+/− murine model of T1DM with the commonly used streptozotocin model and found several important differences in muscle characteristics [14].
The antidiabetic activity of the total ethanolic extract and different fractions of A. hirtum leaves was evaluated using streptozotocin-induced hyperglycemia method [21, 22].
We conducted experiments using streptozotocin-induced diabetic hearts isolated from rats.
Recently we also reported the aortic protection from diabetes-induced damage with sulforaphane in a type diabetic mouse model, in which, however, we have used streptozotocin (STZ) to induce diabetic mouse model [ 44], as used most frequently by others [ 45- 48].
We used streptozotocin to induce a model of type I diabetes in transgenic mice that express green fluorescent protein under the control of an endothelial-specific promoter (Tie2-GFP) allowing rapid isolation of aortic endothelium.
In this study, we used streptozotocin (STZ -induced diabeteSTZ -inducedel, high glucose-indiabetesonanimalat cardiomodeltes and high cardiomyoblasts to detect corin and ANP expression in vivo and in vitro.
The present study used streptozotocin to produce diabetes.
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