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Therefore, predictive in vitro and ex vivo placenta models using human cells or tissue are necessary to avoid species-specific differences.
We applied this therapy to GBM models using human U87MG glioma cells and GBM xenograft models in mice.
For example, they can serve as connectors from rodent proof-of-concept combined optogenetic and cell replacement studies25 to preclinical models using human stem-cell-derived neurons to accelerate translation.
The development and application of pre-clinical models using human OS cell lines and xenografts has been complemented by the development of OS models in other organisms.
Validation of these constitutive models using human data remains challenging and often requires the use of non-invasive imaging and inverse finite element (FE) analysis.
Comprehension of the factors that allow paracrine signalling when cells are not forming a barrier, but are able to communicate amongst them, could help in the design and improvement of future BBB models using human primary cells, identification of therapeutics targets for BBB integrity preservation as well as early detection of toxic effects over each specific cell type conforming the BBB.
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Here we report the first long-term glycemic correction of a diabetic, immunocompetent animal model using human SC-β cells.
Ichiyanagi, N. et al. Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells.
This SnapShot presents a timeline of key advances in directed differentiation and disease modeling using human pluripotent stem cells.
We aim to develop a model using human arteries as vascular grafts in a murine model and to assess the cellular accumulation on these grafts.
To better understand these underlying neurobiological mechanisms and identify novel analgesic targets for pulpally derived pain, we have developed a powerful ex vivo model using human tooth slices.
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example using human
models using stable
models using genetic
models using city-specific
models using multilevel
models resembling human
models using new
models using multiple
models using multilinear
models using para-skilled
models using different
models using residual
models using logistic
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models using maximum
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