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Surprisingly, none of the predictive models using molecular profiles significantly improved over models using clinical variables only.
Very different models using clinical parameters at an early postnatal age to predict BPD have been developed with little extensive quantitative validation.
In particular, systolic BP and age were the two most important variables in models using clinical factors alone or in combination with genetic factors.
Several statistical and machine learning models using clinical and molecular features were evaluated for their ability to distinguish lethal from indolent cases.
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In this study, we have identified significant prognostic models using clinical-pathological variables and 323 gene expression "modules" in patients with lymph node-negative ER-positive breast cancer.
The point-based model using clinical measures may have a useful role in stratifying a population so that those at the highest risk are offered further testing and intervention.
We have shown that PAFR inhibition reduced the risk of NEC in a neonatal animal model using clinical risk factors for NEC (bacterial colonization, intestinal ischemia, and formula feeding) [5].
The initial equation was derived from a model using clinical and demographic variables known to be predictive of CVD events.
a. Logistic regression model using clinical outcome as dependent variable controlling for baseline BPRS or SAI E.
An alternative multivariate model using clinical variables, including creatinine and PfHRP2, was undertaken, but it did not improve the performance of the model (data not shown).
(a) Treatment cost for diabetes-related complications from the UKPDS model using clinical data from the Australian patient sample (b) 95% confidence intervals in parentheses.
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