Sentence examples for models urokinase expression from inspiring English sources

From studying osteoblastic metastases of prostate cancer in preclinical animal models, urokinase expression by the tumor was proposed as a growth factor and as an activator of other bone growth factors; however, the mechanism of action of osteoblastic metastases requires further research.

In the same way, altered Ras gene was reported to increase various MMPs and urokinase expression as well as tumor cell invasion [19], [20], whereas it's suppression resulted in reduced melanoma cell migration and invasion [21].

Further, upregulation of urokinase expression in invasive prostate cancer cell lines correlates with hypomethylation of the promoter (Pakneshan et al. 2003).

ERK1/2 signalling in MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation; there, inhibition of ERK1/2 activity leads to decreased cell proliferation and decreased cyclin D1 expression [ 58].

Normally injury stimulates the local urokinase (uPA) expression [ 5].

Reduced urokinase receptor expression in cells containing the disrupted mutated K- Ras was not due to a physical impairment of the urokinase receptor gene since phorbol ester treatment was inductive for its expression.

Accordingly, urokinase receptor expression was compared in HCT 116 colon cancer cells containing either a mutation-activated K- Ras or disrupted for this oncogene (by homologous recombination).

In conclusion, this model shows the urokinase system is important for bladder invasion and can be used to investigate other mechanisms of bladder cancer invasion and also for the testing of intravesical drugs.

Accordingly, our own group showed that Ras-driven EMT is attenuated via Sorafenib-mediated inhibition of Urokinase plasminogen activator (uPA) expression in RT112 urothelial carcinoma cells [23].

The expression of urokinase plasminogen activator receptor (uPAR) has been shown to correlate with increased metastasis in tumor cells [28] [30] and with drug resistance [31] (for review see [32]).

Urokinase plasminogen activator and urokinase plasminogen activator-receptor expression were analysed by flow cytometry.