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Furthermore, the recent identification of pocket protein-independent pathways regulating G0/G1 arrest in teratoma and cell culture models underscores the need to validate pocket protein networks in specific cell types in vivo (Wirt et al., 2010).
While it is clear that the CEST data do report on native dimer formation, the fact that they can be fitted neither to two- or three-state exchange models underscores the complexity of the system and the difficulty in determining accurate kinetic parameters.
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Recent federal legislation and a renewed focus on integrative care models underscore the need for economical, effective, and science-based behavioral health care treatment.
The human diseases and mouse models underscore the relevance of the N-glycosylation process in mammalian physiology.
Once again, parallel studies conducted in pathogenic versus non-pathogenic SIV models underscore the relevance of our findings in the context of HIV-1 infection.
To date, the amount of measured data is the main bottleneck in learning informative Boolean models, underscoring the need for efficient experimental design strategies.
These different outcomes in different cell models underscore the complexities of interpreting in vitro findings and applying them to in vivo conditions.
Furthermore, current models underscore the critical prerequisite for AQP4-IgG access to the CNS parenchyma across the BBB in order to bind to the extracellular domain of AQP4 on astrocytes and activate complement.
Ectopic expression of these miRNAs, including miR-181a and -223, substantially altered lineage commitment and differentiation and was associated with lymphomagenesis in animal models, underscoring the important regulatory role of miRNA in controlling normal hematopoiesis.
The varying vascular permeability model underscores the integrity of the glycocalyx as one of the key factors involved in fluid dynamics and suggests that its restoration needs to be one of the therapeutic goals in conditions of physiologic stress [49],[49].
The critical importance of affective evaluations in this risk perception model underscores the relevance of attitudinal interventions as informed by the EPPM, for pandemic willingness-related response trainings for EMS personnel.
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