We favorably compare our model to published data from CRISPR-Cas9, CRISPR-Cpf1, CRISPR-Cascade, as well as the human Argonaute 2 system.
The best-fit of the model to published data is shown in Figure 1B.
We describe phases of the model development process: defining the model structure or health states; specification of model parameters and assumptions; and estimation of parameters by calibrating the model to published studies and SEER data.
In this paper we derive a thermodynamic model for microtubule dynamics and use this model to perform Monte Carlo simulation where we include the contribution of water to the entropy of the system and we fit all the parameters of our model to published experimental data including the hydrolysis rate of GTP.
We fit the differential equation model to published microarray data using a penalized nonlinear least squares approach.
Observations from recent application of the validated H1 seroarcheologic model to published data linked preexisting H3 antibodies to the pandemic of 1890 (32 ).
Finally, estimates of r are obtained by fitting the Markov model to published incidence rates from the Centers for Disease Control and Prevention (using the National Health Interview Survey) (5).
In a specific network of placebo-controlled trials of antidepressants, based on data already described and published previously by Turner et al., comparing the results of adjustment models applied to published data and those of the standard NMA model applied to published data allowed for assessing the robustness of efficacy estimates and ranking to publication bias or related small-study effects.
Codes are reported in the Additional file 1: Appendix 2. We compared the results of the 2 adjustment models applied to published data and results of the standard NMA model applied to published data and the FDA data, the latter considered the reference standard.
In adjustment models applied to published data, between-trial heterogeneity and fit were comparable to those obtained with standard NMA of published data (Tables 1 and 2).
