Sentence examples for models to novel from inspiring English sources

If successful, Fragile X will be the first psychiatric disorder in which a potentially curative treatment was developed mechanistically from gene identification to pathophysiology in animal models to novel therapeutics in humans.

Both points mentioned require an adaption of a given model to novel cases, and we plan to utilize methods from incremental learning [47] and domain adaptation for this task.

Overfitting also affects the application of a climate model to novel conditions (those climates not considered in the calibration of the original model).

The applicability of the prediction model to novel targeted agents remains to be tested in future clinical trials.

Our work shows activation dynamics of signaling molecules can be used in conjunction with perturbation-response models to decipher novel signaling features of complicated immune pathways.

Mice with deficient or mutated aquaporin are currently used as models to study novel cellular roles of human aquaporins [ 11].

With the ongoing need to improve therapy for non small cell lung cancer (NSCLC) there has been increasing interest in developing reliable preclinical models to test novel therapeutics.

We used new cell line models to characterise novel chemotherapy resistance mechanisms and validated them in tumour specimens to identify new targets and biomarkers for gastroesophageal cancer.

Thus, both these studies demonstrate the power of high-resolution live imaging in zebrafish models to visualize novel cellular events that underlie pathology.

Clinical trial design should be adapted to use preoperative and neoadjuvant models to allow novel therapies to be tested in patients [ 394, 407], identify de novo resistant cancers and investigate how such resistance can be counteracted.

Given the high sensitivity of NGAL for AKI post cardiopulmonary bypass, this study provides a model to use novel AKI biomarkers in a novel manner.