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The knowledge gained from comparative observational studies has served as a base for experimental interventions in animal models to induce or ameliorate scar.
When further engineered to express cytokines, chemokines, tumor-associated antigens, or other immunomodulatory elements, they have been shown in various preclinical models to induce antigen-specific effector and memory responses, resulting both in full therapeutic cures and even induction of life-long tumor immunity.
Optimal supercritical conditions can be experimentally derived and aided by models to induce the ideal combination of temperature, pressure, and residence time [18].
Aortic banding has been routinely applied in larger animal models to induce cardiac remodeling [30].
Acute stress is used in animal models to induce behavioral, physiologic and neural changes relative to human depression [ 30].
We compare and discuss different models to induce peritoneal adhesions in a randomized, experimental in vivo animal study with 72 female Wistar rats.
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In order to determine if IL-10 affects developmental angiogenesis in the retina, we utilized the oxygen-induced retinopathy (OIR) model to induce tissue ischemia and compensatory retinal neovascularization [17].
We used the lithium-Pilocarpine model to induce epilepsy33.
These act in a coordinated manner, according to the so-called 'balance model', to induce hypersensitive programmed cell death at the infection site to restrict pathogen growth5.
Alsafadi, H. N. et al. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices.
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