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This book touches on all of these, with a particular focus on topics such as domestic animals as comparative models to humans, molecular regulation of growth, metabolic efficiency, reproduction, and the impact of stress on growth and development.
The failure to translate promising drug candidates from animal models to humans has led to questions about the utility of in vivo studies and to demand for more predictive models and tools based on the latest technologies.
These can be used to perform in silico simulations to promote unravelling the relation between architecture and function as below illustrated for liver regeneration, and bridging from the in vitro situation and animal models to humans.
But to extend observations from these animal models to humans, several factors must be borne in mind: the impact of the complex and varied genetics of humans; the effect of different reagents used and different responses to treatment modalities; the impact of concurrent and complicating co-morbidities in the patient; and the ability to regenerate an immune system after lymphoablative therapy.
The judicious interpretation and extrapolation of data derived from these models to humans, and a correspondingly greater emphasis placed on translational medical research in early stage clinical trials, are essential to improve on the current clinical attrition rates for novel oncology therapeutic agents.
UNLABELLED: The purpose of this study was an attempt to extrapolate favorable observations on the effects of magnesium on platelets and haemostasis from animal models to humans.
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Contributions of the amygdala to emotion processing: from animal models to human behavior.
Chesneau, M., Michel, L., Degauque, N. & Brouard, S. Regulatory B cells and tolerance in transplantation: from animal models to human.
It seems safe to say that most economists also apply these models to human behavior only as approximations.
Many researchers seek to fit dynamical models to human coordination of simple motor tasks.
Finally, we will identify distinct murine monocyte populations and link their function in preclinical animal models to human monocyte function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com