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In turn, this leads to difficulty in translating findings from human studies into animal models to dissect pathophysiology.
The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing.
Thus areas of interest could include (but are not limited to) the genetics and epigenetics of human cancer, tumor-host interactions, tumor metastasis, tumor immunology, and the use of mouse models to dissect mechanisms of tumor initiation and progression.
Areas of interest include (but are not limited to) the genetics and epigenetics of cancer in humans or mouse models, tumor-host interactions, tumor metastasis, tumor immunology, cancer genomics, and the use of mouse models to dissect mechanisms of tumor initiation and progression.
Here, we use genetic mouse models to dissect the roles of Mcl-1 in primary T lymphocytes.
Second, it is crucially important to have explicit models to dissect the effect of mutation and selection.
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The nematode Caenorhabditis elegans is an attractive model to dissect the mechanism of axonal regeneration3.
But we cannot use an econometric model to dissect the phenomenon beyond simply noting that a significant relationship exists between the false alarm rate and increased casualties.
Owing to its numerically simpler nervous system and a battery of genetic tools, Drosophila offers an unusually powerful model to dissect the molecular and neural mechanisms of circadian behaviour.
The system supports controlled, effective delivery of treatments (dsRNA/hsiRNA) to the apical intestinal membrane with relatively minor off-target effects, and builds on our experimental model to dissect A. suum intestinal cell functions with broad relevance to parasitic nematodes.
In this study, we combined an in vivo experimental approach and mathematical modelling to dissect the contributions of some of the circulating hypotheses proposed in driving bacterial outgrowth in IAV pre-infected hosts with the main focus on pro-inflammatory cytokines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com