An additional study demonstrated that while pegylated G-CSF limits the severity of the radiation-induced cytopenias in an ARS rodent model, this agent appears to be less efficacious in treating irradiated animals with substantial skin burns (15% total body surface area skin burns) [ 77].
In view of possible antitumour experiments combining NU7026 with radiation in animal models, pharmacokinetic modelling of this agent is also presented that suggests a schedule of administration.
Importantly, pharmacogenetic factors explain a significant portion of inter-patient variability and improves the accuracy of a developing population PK model for this agent.
The activity of R306465 in a panel of different human tumour xenograft models suggests that this agent may have applicability against a broad spectrum of human malignancies.
Preliminary studies with chicory carried out in the collagen-induced murine arthritis model showed that this agent reduced joint swelling with a magnitude similar to the NSAID indomethacin (unpublished data, Phytomedics).
15 Also, in experimental models of acute dermatitis, this agent exerted topical anti-inflammatory effects.
In this model, the agents measure the quality of a good (Q) on a scale from 0 to 1, where 0 represents a good with no credence qualities.
It is important to mention that if a given therapeutic agent has an influence that is not represented by any of our model's parameters but corresponds with the in- or outflux of a model variable, the effect of this agent can be translated in our model by a change in the respective rate constant γi.
This agent model is biologically inspired in the emotion mechanisms found in the brain, following recent neurophysiological research.
The results from this agent model highlight the importance of flight as a topic for research even a small amount of flight can have a dramatic impact on epidemic dynamics.
