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Previous studies on tauopathy mouse models have obtained divergent results with regard to dendritic spines: While in most models, the spine density was found to be reduced [ 8- 10], in others an increased [ 12] or unchanged spine density [ 13] was observed.
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Beam, spring and mass elements were used to model the spine, viscera, head, pelvis and buttocks tissue in the mid-sagittal plane.
A 5-cm-diameter cylinder filled with a K2HPO4 solution was set in the container in order to model the spine attenuation.
To investigate the effect of morphology on calcium dynamics we modeled the spine as a sphere and the dendrite as a cylinder.
With this standard, we attempted to reflect various shapes of spines, which are difficult to approximate by using circles to model the spine.
To accommodate this observations, we model the spine as a self-contained diffusion compartment corresponding to a sphere of the same volume as a large dendritic spine (see Table 1).
In the Ace-1 metastatic model, the spine, right and left femurs, and tibias were excised and fixed in 10% buffered formalin for one week to allow radioactive decay.
That is, looking at the development process, besides a spine of model transformations moving from highly abstract, domain related models down to concrete platform related models (programs), we can see a number of barbs, relating models in the spine to specialized models that permit specific analysis of parts of the software.
The linear model and the spine model had almost the same DIC (1325.7 vs. 1325.9), but the spline model indicated that the association could be a cut-off type rather than linear so that the units treating about 25 or more hip fracture patients per year would have better results.
Lumped parameter models of the spine have been developed to investigate its response to whole body vibration.
The application of kinematic data acquired during biomechanical testing to specimen-specific, three-dimensional models of the spine has emerged as a useful tool in spine biomechanics research.
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