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By integrating all the new data in more and more sophisticated models, the major goals may emerge from the characterisation of new markers for diagnosis and prognosis and from the selection of pertinent and efficient new therapeutic targets.
Here, we discuss the insights derived from RSV human challenge models; the major impediments to their more widespread uptake; and their potential benefit in accelerating vaccine development, including future directions to further enhance the relevance of these models to at-risk patient populations.
In addition, in these models, the major part of the true biological interactions between the gene and environment is often partitioned into the marginal effects.
For all the models, the major changes can be found between the control run, 1961 1999, and the 2081 2100 period.
We therefore believe that, in our mouse models, the major driver for the enhanced metastasis is the MCs.
Although this model does not reflect the natural environment of the peritoneal cavity, it bears in contrast to conventional intraperitoneal endometriosis models the major advantage that the lesions are easily accessible for intravital microscopic analyses (Laschke and Menger, 2007).
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Out of this model, the major mechanism leading to the high Zigbee PER is identified.
From the Boyd's model, the major rate controlling step was observed to be film diffusion.
To optimize the design, detailed computer simulations allow the engineer to accurately model the major loads and interactions.
In the mesh-free particle model, the major issue is how to calculate interaction between particles at different layers in an MWNT to approximate molecular-level interlayer interaction.
Although in the mRNA trap model, the major role of circRNA is the linear splicing competition, one cannot rule out certain function by circular RNA itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com