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Hypoxic stress results in a significant increase in erythropoietin (EPO) mRNA in mouse brain and, in two models, the administration of EPO improves performance function and prevents cognitive impairment.
In sepsis models, the administration of exogenous sRAGE slightly improved survival [ 22].
In Cox proportional hazard models, the administration of PSK decreased the risk of recurrence and that of lymph node metastasis and a lower primary tumour.
In animal models, the administration of an amino-acid mixture lacking the cathecolamine precursors tyrosine and phenylalanine decreases the availability of plasma tyrosine to the brain, which further diminishes cathecolamine synthesis [ 16].
In several animal models, the administration of antibodies against IL-1 has been shown to protect against systemic and local inflammation (e.g., arthritis) and to decrease the histopathological findings of inflammation and osteoarticular destruction [ 2].
In animal models, the administration of sPLA2 inhibitors reduced lung inflammation and improved both compliance and oxygenation, especially if the inhibitor is administered early during the injury development [ 8, 14].
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In the same model, the administration of an inhibitor antibody against TNF-α prevented the systemic increase in PAI-1.
In animal model, the administration of contrast media resulted in an increased excretion of endogenous adenosine.
In our model, the administration of different bile acids led to several effects.
In a murine tumor model, the administration of siRNAs reduced tumor growth rate.
In a rabbit model, the administration of ascorbate aggravates damage, likely through the abrogation of the endogenous enzymatic antioxidant response triggered by short episodes of ischemia [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com