This observation could explain why no sufficient ASPM-deletion mouse models that recapitulate microcephaly phenotypes have been developed.
In this review, we describe preclinical in vivo models that recapitulate many of the features of asthma and COPD.
Few animal studies have evaluated the relationship between migraine and mental disorders, possibly because animal models that recapitulate the pathophysiology of migraine are scarce.
Moving forward, new methods to quickly generate animal models that recapitulate the complex genetics of human hematological disorders are needed to transform the genetic information to new therapies.
Herein, we examine major C. elegans neurodegeneration models that recapitulate many aspects of human neurodegenerative disease and we survey the screens that have identified modifier genes.
The rabbit model is particularly poised to become one of the most popular among the animal models that recapitulate human heart diseases.
With new advances in tissue culture and engineering, these model systems are able to provide increasingly accurate, high-throughput and cost-effective models that recapitulate important characteristics of cell and tissue growth in vivo.
To facilitate these studies, we have developed and optimized 3D organotypic co-culture models that recapitulate the in vivo interactions of mammary epithelial cells or tumor cells with stromal and inflammatory cells.
The following chapter aims to introduce and discuss 3D cell-based in vitro models that recapitulate both the architecture and multicellular complexity of an organ/tumor in vivo but at the same time accommodate systematic experimental intervention.
In light of this, in vivo experimental mouse models that recapitulate human malignancies serve as valuable tools to validate the efficacy and safety profile of immunotherapy agents, before their transition into clinical trials.
To tissue-engineer models that recapitulate three-dimensional architecture and signaling in tumors, there is a pressing need for new materials permitting flexible control of mechanical and biophysical features.
