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It ameliorates the manifestations of diabetes in preclinical models, suggesting potential applications for the treatment of diabetic patients.
In a number of cases, antisense reads were markedly clustered at the 3' end of the exon of predicted gene models, suggesting potential bidirectional promoter activity [ 23].
12 At low concentrations, selenite can increase cell proliferation and suppress apoptosis, while higher concentrations decrease cell proliferation and cause apoptosis in several cancer cell lines and animal models, suggesting potential clinical applications.
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In addition, data obtained in animal models suggest potential benefit of DPP-4 inhibition on EPC pro-angiogenic activity [ 16, 17].
Similar pathways emerged from the analysis of potential targets of four miRNAs that showed a treatment response in the plasma of HNSCC patients and the cell culture model, suggesting potential molecular therapeutic targets in the E2F transcription factor network and the PTEN/AKT signaling pathway.
We provide evidence that ICL1 is significantly involved in G-protein activation and our model suggests potential interactions with subunits Gα as well as Gβγ.
Soybean peptides such as VPY and others have shown promise in controlling cytokine/chemokines levels, reduction of oxidative stress, and reversal of the tissue damage observed in animal models of colitis, suggesting potential applications in treatment of inflammatory bowel diseases [ 55, 56].
In some cases, these compounds have also been shown to be protective in mammalian ND models, suggesting translational potential for human patients.
Broadly neutralizing antibodies (bNAbs) against HIV-1 provide both effective pre-exposure prophylaxis and treatment of HIV-1 infection in murine and nonhuman primate models, suggesting their potential use in humans.
IL-33 - which binds to a member of the IL-1 receptor family, inducing similar intracellular signals to IL-1 - is also expressed in human synovial fibroblasts with increased expression in arthritic joints of murine models, suggesting a potential role in the pathogenesis of arthritis [ 18].
In this structure, four extensive intermolecular interfaces are observed, suggesting potential models for APOBEC3G oligomerization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com