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Preclinical models suggest robust activity for dual IGF-1R and mTOR inhibition [ 62, 63].
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41 We will also identify factors that are contingent or context specific, and integrate these into the model where they suggest robust underlying mechanisms that shape the potential for supportive interventions.
The robust results of O3 observed from different models suggest that it may have effects on GDM independent of PM2.5.
Models suggest it could.
Some models suggest there could well be.
Our toy models suggest three things.
The strong canalization of these GRN models suggests that they must also be robust.
Although this level of multiple comparisons increases the chance of finding a variable associated with retention as a result of chance alone, the consistency of these findings across the models suggests that the factors identified are robust predictors of retention.
The landscape model suggests that both robust, difficult-to-alter T-cell phenotypes and flexible T cells with further differentiation potential may be represented just by quantitative changes in the shape and relative depth of the attractor basins.
Interestingly, recent theory and modelling suggests that GC may be robust to haemodynamic variations but not when combined with down-sampling and measurement noise [ 44].
However, the CO effect estimates remained robust in a two-pollutant model, suggesting an independent CO effect on birth weight in the first trimester.
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