Similarly, a number of Leishmania mutants have been generated with defects in pathways for de novo synthesis of other metabolites (glycine, amino sugars) or nutrient salvage pathways (nucleotide/nucleoside/purine base) that retain virulence in animal models, suggesting considerable redundancy in nutrient uptake/ de novo biosynthetic pathways.
Similarly, adding a knot on day 30 led to no improvement in fit; in fact, the BIC statistic for this model suggests considerable loss in fit.
We found that increasing Ων weakens the requirements to the value of T/S, however even for Ων ≤ 0.4 the models with h + n ≥ 1.5 suggest considerable abundance of gravitational waves, T/S⪆0.3.
The consistent level of correlation (of 0.6 0.7) found between the measure and the other constructs suggest considerable scope for the development of a comprehensive biopsychosocial model with the Stroke-QoL as an endpoint or primary outcome.
The results suggest considerable potential for transcriptional divergence between closely related vertebrate species and highlight the tiger salamander/axolotl model system for examining mechanisms in the developing brain that determine adult phenotypic outcomes.
The electrochemical studies suggest considerable donor acceptor interaction.
Our data suggest considerable psychosis morbidity in diverse, rural communities.
They also assume that spending cuts fall overwhelmingly on transfers, not on government purchases; their own model actually suggests considerable impact from declines in purchases.
Despite the cost-effectiveness of treating PWID, the actual costs of HCV treatment, particularly DAAs, will challenge governments in both developed and resource-limited settings; nonetheless, the models suggest standard HCV therapy still has considerable benefits.
A recent study based on high-resolution bathymetry data provides strong evidence showing that no significant motion occurred on the 40-km-long offshore Yalova segment located to the west of the Golcük segment (Cormier et al., 2006), though modeling of geophysical data suggests considerable displacements (Wright et al., 2001; Gülen et al., 2002).
