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Current studies on toxic effects of NPs aimed at identifying the targets and mechanisms of their harmful effects are carried out in cell culture models; studies on the patterns of NP transport, accumulation, degradation, and elimination, in animal models.

Similar to animal models, studies on A. thaliana miRNA-action mutants have revealed the existence of translational repression by miRNAs [ 30].

In animal models, studies on the influence of combined controlled mechanical ventilation and short-term high-dose methylprednisolone have given inconsistent results in regard to the effects on diaphragm muscle function.

As an alternative to human breast cancer cell lines and xenograft models, studies on steroid signaling and mammary cancer are being performed in rat models that, unlike mice, exhibit a significantly higher frequency of ER-positive lesions.

Of the many translational research involving animal models, studies on the pathogenesis of cartilage disease is of great importance and has been extensively carried out in view of its great implication in further management of osteoarthritis, a disease that is associated with a huge medical and economic burden to the nation [ 3, 7- 9].

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(f) The number of bioclimatic model studies on crops greatly exceeds that of those on forest plants.

(c) The number of bioclimatic model studies on woody plants is substantially higher than that of those on herbal plants.

Generally, there is a paucity of animal model studies on effects of fluid resuscitation on the microcirculation.

Regarding other bioclimatic models, only a few model studies on fruit ripening bioclimatology were found (Piper et al. 1996; Song and Ou 1997).

(b) The number of bioclimatic model studies on temperate plants is considerably higher than that of those on tropical and subtropical plants.

A conceptual model of perched water occurrences is discussed, and a series of comprehensive computer modeling studies on perched water at the site are presented.

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