HRs and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by the factors used for the stratified log-rank tests and by treatment.
To determine if region of origin acted as an effect modifier, we conducted a stratified multivariate analysis by creating eight identical models, stratified by the eight world regions.
We also performed exploratory analyses in which we ran multivariable-adjusted models stratified by age (<55 years of age compared to ≥55 years of age).
The analysis procedures were conducted separately in time series models stratified by status of temperature sensitivity (i.e. temperature sensitizer vs. temperature non-sensitizer groups).
We additionally fit our final models stratified by survey year.
Village was included in all models a priori, whilst in models stratified by age, sex was included a priori and age (in years) was included a priori in models stratified by sex.
In multivariate models stratified by gender and marital status, HIV infection was strongly associated with age, higher number of sex partners, widowhood, and HSV-2 seropositivity.
All models stratified by clinic cluster.
Table 6 shows results for models stratified by medication use.
Multivariable: models stratified by age in months, adjusted for race.
Finally, we ran the models stratified by smoking status.
