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This method is not unique among initial aircraft design tools, but unlike these tools, which take into account only several main constraints, Hoburg's method allowed the team to consider around 200 constraints and physical models simultaneously, and to fit them all together to create an optimal aircraft design.
The key is operating both models simultaneously and leveraging each for the betterment of the other.
Five environmental barriers generating the most P-E fit problems in each housing section were included in the models simultaneously and first adjusted for age and sex.
In the present study, we designed the communication box to induce PS and PCS in mice because this device can induce both PS and PCS models simultaneously and aid in investigating the physical and physiological changes under psychological stress conditions [ 28, 29].
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A computational algorithm based on constrained non-linear optimization is developed to estimate the essential parameters in the CTF and envelope function model simultaneously and automatically.
How can traditional univariate associations be modeled simultaneously and in the absence of a correlation threshold?
All variables were included in the model simultaneously and treated as independent variables.
Model 1: All the environmental barriers in each housing section are included in the model simultaneously and adjusted for age and sex.
All candidate predictors were entered into the model simultaneously, and those that were statistically significant (P < 0.05) were retained in the final model.
Endogenous and exogenous IgG (i.e., the administered mAbs) are modeled simultaneously and compete for FcRn binding in the endothelial space.
Model 2: All the environmental barriers in each housing section are included in the model simultaneously and adjusted for age, sex, depressive symptoms, cognitive functioning, years of education, monthly income and number of functional limitations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com