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The combination of SS1P with chemotherapy is based on results from in vivo mouse models showing marked synergy between SS1P and chemotherapy [23] [26].
In a study on two HF diet fed mouse models, showing marked susceptibility (C57BL/6J) or resistance (Balb/c) to NAFLD and insulin resistance phenotype, significant up- or down-regulation of key genes which may be involved in homeostatic adaptation to HF regimen has been detected.
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Consistent with the immunoblot results, LC-staining of frozen sections from different groups of mice models showed marked increases in autophagy in the lungs of ALI mice, whereas the administration of C5a antibody significantly inhibited the induction of autophagy in ALI mice.
The revised model shows marked improvement over standard MMC closure in predicting velocity statistics close to the nozzle.
Residuals from the model showed marked patterning when plotted against year, violating the assumption of homogeneity.
In support of the above finding, another study using STZ induced type 1 diabetes model showed marked decrease in the level of miR-133a which was associated with hypertrophy and contractile dysfunction at 2 months after induction of diabetes [ 95].
In vivo animal model studies show marked inhibition of T-L activity in response to NPI-0052, whereas Bortezomib enhances T-L proteasome activity.
When compared to the other 2-D inverse models, profile 2 shows marked low resistivity values suggesting the presence of highly conductive fluid or rock type (Fig. 12b).
Baseline R2* values for the two xenograft models overlapped and both showed marked heterogeneity ranging from 15.4 to 135.0 s−1.
MB in model surfactant lipid mixtures showed marked in vitro activity, with spread films exhibiting near-zero minimum surface tension during cycling using captive bubble surfactometry [48].
For the cylindrical model, only the result from Lb-1 is shown (marked, CYL) because results from the four cylinder fits are all close to each other.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com