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In addition, all three models show evidence for the involvement of mitochondria in cytosolic aggregates, consistent with prominent roles of mitochondrial dysfunction in ALS.
Mouse models show evidence of oxidative stress, particularly in white matter (Hagemann et al., 2006), and the cell culture models display increased sensitivity to camptothecin-induced apoptosis and H2O2-induced cell death (Tang and Goldman, 2006; Cho and Messing, 2009).
Although the few data from experimental animal models show evidence for transgenerational inheritance, also for early nutritional environmental exposures, further investigations in these models are clearly needed to unravel the underlying mechanisms.
Though the plot for the 1988–1998 Pmodelmodel residuals shows only limited evidence of autocorrelation, plots for the other two models show evidence of modest autocorrelation at a lag of one month and, to a lesser extent, seasonal dependence (at lags ~12 months) not accounted for in the modeling.
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None of the models showed evidence of a lack-of-fit.
Both the MFP and SC tumour models showed evidence of poor lymphatic drainage, as several CD31 negative and collagen IV-lined fluid-filled cavities were observed.
However, the 1-day and 2-day lag models showed evidence of interaction of elemental carbon and nitrogen dioxide with zinc (p for interaction < 0.01).
Although the xenograft models showed evidence of invasion in the presence of anosmin-1 (Fig. 7), the microenvironment of the brain parenchyma is different from that of flanks, thus the effects of anosmin-1 in brain tumor invasion will need to be reconfirmed in orthotopic models.
The model shows evidence of a pronounced local effect that is significantly greater than the global effect.
The geospatial crop model showed evidence of both spatial and temporal variability of crop yield at the county level.
However, neither regression model showed evidence of such a relationship.
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CEO of Professional Science Editing for Scientists @ prosciediting.com