Similar to that observed in doxorubicin-resistant CML cell lines [23], [24], our tissue culture models showed enhanced basal phosphorylated Akt in tamoxifen-resistant cell lines compared with the parental sensitive cell line MCF-7.
In addition, MRI and photothermal effect for mouse model showed enhanced T1 signal and temperature elevation in tumor site with photoirradiation.
Comparisons were made between simulated results by the finite element analysis and corresponding experiments and the newly proposed model showed enhanced prediction capability, which was also supported by the simple bending analysis adopting asymmetric stress strain response.
Pro-aggregant tau resulted in impaired L-LTP in the CA3-CA1 hipathwayal pathwhilewhile an anti-aggregant tau model showed enhanced CA1-LTP [ 19, 58].
Overexpression of CD73 on B16-F10 melanoma cells which were injected intravenously in the murine model showed enhanced metastasis into the lung while similar to our results, local growth was not affected after subcutaneous inoculation [ 10].
Furthermore, pre-clinical studies of a HER2-positive human gastric cancer xenograft model showed enhanced anti-tumour activity when pertuzumab and trastuzumab were combined, compared with that seen with either antibody alone (Yamashita-Kashima et al, 2011).
Woodward championed a so-called β-lactam structure, which contained a cyclic amide fused to a five-membered ring2 (Fig. 1c), whereas another group, led by Robert Robinson, noted that model β-lactams did not show enhanced penicillin-like reactivity and so strongly favoured an alternative molecular arrangement.
Finding enhanced L-LTP and impaired behavioral performance may seem at first glance to be counterintuitive, but other mouse models have shown enhanced LTP and impaired memory [ 49- 51].
Finally, the efficacy of iRGD peptide co-administration with GEM was verified using five pancreatic cancer models that showed enhanced drug accumulation in dextran experiments.
According to [10] and [18], this model had shown enhanced results over the isotropic model when checked with hourly calculation based on long-term period of radiation data.
