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The LTL PDX models retain key biological properties of the original malignancies, including histopathological and molecular characteristics, tumor heterogeneity, metastatic ability, and response to treatment.
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This tractable and reliable model retains key characteristics of the human disease, including vascularity and aggressive invasion into surrounding tissue, and an intact immune system.
Private donors are also stepping up efforts to retain key scientists.
Adding to the utility of these models, primary tumors are used as substrate to generate tumor-derived cell lines that maintain much of the biology of the original tumors, and retain key alleles of interest (Martin et al., 2013).
Hence, the GBM orthotopic model retained the key features of de novo TRP glioblastoma tumors while recapitulating human GBM histopathology in an immunocompetent background (Motomura et al., 2012; TCGA, 2008).
It also retains key ministerial portfolios.
Then there is the matter of retaining key personnel.
"We've retained key players: Stuart Hogg, Tommy Seymour, Henry Pyrgos, Josh Strauss, Leone Nakarawa, Adam Ashe, Lee Jones and Peter Horne.
Some of the acquisition money will go to retaining key employees.
It's vital for attracting and retaining key talent.
BWA-SW retains key information of alignments and generates much smaller and more convenient output.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com