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However such models require significant computational resources.
However, a priori knowledge cannot be used in unstructured environments and three-dimensional models require significant computation in a cluttered environment.
Many of these models require significant interventions such as exposing the aorta and subsequently infusing or painting elastolytic solution on a segment of the artery to induce weakening and inflammation.
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Implementing and scaling these circular business models requires significant financial investment.
It should be noted that the calculation of large models requires significant CPU resources.
Further, working with mouse models requires significant time and expense to create and study the appropriate phenotypes, thus preventing the use of these animal models in high-throughput screens for genetic pathways that may either enhance or suppress the phenotype.
Based upon our previous studies on the ODE model of CD4+ T cell differentiation and agent-based modeling for enteric immunity, it is concluded that developing multiscale models requires significant reduction of the intracellular ODE model before integrating them into the inter-cellular agent-based models.
Since this complete model requires significant computational time, a reduced model of chloride ingress is afterwards proposed.
This model requires significant computational time, which prevents its application in on-line control and supervision systems.
Keeping them engaged in a centralized model requires significant effort with frequent local visits and community meetings that include the study leadership.
Although this E1/Rho-like model requires significant motor/DNA distortions (5 SpoIIIE subunits span an arc of 300° while five consecutive phosphates in dsDNA span an arc of ∼170°), it is in principle consistent with the data from Figure 2.
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