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In conclusion, these mouse models represent valuable experimental paradigms for human pathogenesis.
Mouse models represent valuable paradigms for studying retinal neurodegenerative and vascular disorders that are analogous in humans.
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Models also represent valuable strategic tools for policy makers evaluating contingency, mitigation, and abatement strategies and the need for mechanistic models to supplement statistical approaches has been increasingly recognized in recent years (Pascual et al. 2006).
Nevertheless, these models represent very valuable tools to study principle functions of miRNA signaling and provide further insights into the role of miR-125b targets in carcinogenesis.
These ganglia represent valuable models for the study of neuronal functioning which explains why they have been studied for more than 30 years using electrophysiological, pharmacological, immunohistochemical and biochemical techniques.
VT2OcKO mice and conditional ES cells may represent valuable models to study and better understand this process.
Effective strategies already in place in several European countries, which have achieved large reductions in colorectal cancer mortality since 1970, represent valuable models for the design and implementation of such public health policies.
Although being structurally similar to febuxostat, these optimized inhibitors bear some structural freshness and could be adopted as hits for hit-to-lead development and further evaluation by in vivo studies towards novel drug candidates, and represent valuable model structures for design of novel XO inhibitors.
Moreover, as they appear to mimic the clinical observations of shared cross-resistance between CDDP, CBDCA and CHIP, they may represent valuable preclinical evaluation models for the discovery of drugs capable of conferring responses in CDDP-refractory ovarian cancer.
Such gaps may represent valuable opportunities for future work.
To DARPA, those reactions represent valuable data.
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