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However, to extend modeling capability beyond simple ideal mixing models remains a challenge.
Calibrating watershed-scale hydrologic models remains a critical but challenging step in the modeling process.
Despite the recent progress, the efficient solution of cell population balance models remains a challenging task.
Nevertheless, the computational effort to run these models remains a substantial constraint on their application.
Anyway, the parameters identification of these models remains a heavy work.
Recent yarn-based simulation techniques permit realistic and efficient dynamic simulation of knitted clothing, but producing the required yarn-level models remains a challenge.
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Nonetheless, the most optimal length of the term of utility models remains an open question.
For these reasons, the efficient resolution of robust topology optimization with large models remains an important computational challenge.
But whether the company will develop a viable or truly innovative alternative to established models remains an open question, as Ms. Lopez readily acknowledges.
To explore these functions in mouse models remains an exciting challenge for the future.
However, the high cost associated with nonhuman primate models remains an obstacle for large-scale studies.
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